Indeed, our findings in clinical samples revealed that the plasma SCUBE1 concentration was high in ACS (n = 40) and AIS (n = 40) patients (median 205 and 95.1 ng/ml, p < 0.01), but it was virtually undetectable in healthy controls (n = 40) and people with chronic coronary artery disease (n = 83) [71]. The gene discussed is SCUBE1; the disease is androgen insensitivity syndrome.