SCUBE1 and acute myeloid leukemia: SCUBE1 expression in AML and primary AML samples has been examined, revealing that SCUBE1 expression is upregulated in mixed-lineage leukemia gene-rearranged (MLL-r) AML cells, as compared to healthy hematopoietic stem and progenitor cells, peripheral blood cells, or leukemic cells devoid of the MLL gene rearrangement [44].