In addition, the ADC can selectively kill SCUBE1-expressing MLL-r leukemia cells (THP-1 or NOMO-1) but not SCUBE1-negative KG-1a or K562 leukemic cells in vitro, and it can suppress MLL-r leukemia growth in a xenograft model [44]. The gene discussed is KMT2A; the disease is leukemia.