We found that the expression of CDH4 is higher in cholangiocarcinoma (CHOL), Colon adenocarcinoma (CAOD), KIRP (Kidney renal papillary cell carcinoma), KIRC (Kidney renal clear cell carcinoma), THCA (Thyroid carcinoma) and HNSCC than normal tissues adjacent to the cancer. The gene discussed is CDH4; the disease is head and neck squamous cell carcinoma.