We analyzed the expression of CDH4 in HNSCC and OSCC in the database, and combined with the analysis of CDH4 in our own tissue samples, we found that the expression of CDH4 is higher in cancer tissues than in normal tissues adjacent to cancer, which may remind that CDH4 promotes the occurrence and development of OSCC. The gene discussed is CDH4; the disease is head and neck squamous cell carcinoma.