In bacterial sepsis, recognition of PAMPs by specific cell surface receptors is critical for activating the immune system and precipitating inflammatory responses [9], including Toll-like receptors (TLRs), nucleotide-binding oligomerization domain like receptors (NLRs), C-type lectinreceptor (CLRs), etc. Specifically, the Receptor for Advanced Glycation End Products (RAGE) is a major cell surface molecule involved in advanced glycation end products (AGEs) toxicity and plays a crucial role in inflammatory responses. Here, AGER is linked to bacterial infectious disease with sepsis.