The effect of NY0123 on breast cancer cells was further detected and showed that CYD0281 significantly inhibits cell viability of MDA-MB-231 cells (Supplementary Fig. 4A), and induces cell apoptosis, PARP cleavage, and Bcl-2 BH3 domain exposure in MDA-MB-231 cells (Supplementary Fig. 4B-D). The gene discussed is BCL2; the disease is breast cancer.