The present study confirms that BOADICEA remains well-calibrated after the addition of PALB2, CHEK2, ATM, BARD1, RAD51C and RAD51D. It also establishes that the model remains significantly better than chance to discriminate between carriers and non-carriers of PVs in BC/OC susceptibility genes, such as CHEK2, in which PVs only add moderately to the risk of BC/OC. Here, PALB2 is linked to breast cancer.