Furthermore, the proportions of tumor-infiltrating anti-tumor immune cells, such as CD4+ T cells, CD8+ T cells, activated CD8+ T cells, NK cells, and M1 macrophages, were all greatly enhanced, whereas the proportions of anti-tumor immune cells, such as Treg and M2 macrophages, were markedly reduced by combined treatment (Fig. 7f–l). The gene discussed is CD4; the disease is neoplasm.