To address the clinical relevance of the AKT/p-IWS1 pathway in patients with LPS, the expression of AKT1, AKT2, AKT3, phospho-AKT (Thr 308), phospho-AKT (Ser 473), IWS1 and phospho-IWS1 (Ser 720) in 33 retroperitoneal LPS tumor specimens and 20 adjacent normal adipose tissue specimens was examined by Western blotting (Fig. 1A and Supplementary Fig. 1A). This evidence concerns the gene IWS1 and neoplasm.