These genes were uniquely enriched in specific pathways, with the enrichment of the Chemokine signaling pathway, Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Rap1 signaling pathway, Natural killer cell mediated cytotoxicity, which suggest the involvement in the regulation of tumor, signal transduction, and cellular immunity (Fig. 2c). Here, PIK3CA is linked to neoplasm.