Parental age was higher for de novo variants with AD inheritance, with a mean paternal age at conception of 35.3 years for fathers of pediatric patients with de novo variants compared to a mean age of 32.3 years for inherited AD and AR variants (P = 0.05) and a mean age of 32.1 years for patients receiving negative results (Supplementary Table 7). Here, AR is linked to Alzheimer disease.