MAPT and Alzheimer disease: Conversely, the cryo-EM structure of AD tau PHFs incubated with the green tea molecule Epigallocatechin gallate (EGCG, a compound known to disaggregate amyloid filaments in vitro)28 shows several unique densities along the filament surface, and model building indicated that the most well-defined density represented EGCG with aromatic rings stacked perpendicular to the fibril axis29.