SFTPB and lung cancer: Among the four loci, rs1130866 at 2p11.2 is a missense variant (Ile131Thr) of SFTPB, encoding surfactant protein B. Pulmonary surfactant lines the alveoli of lung to reduce the surface tension and is essential for lung function, and increasing circulating level of pro-SFTPB suggested increased lung cancer risk based on prediagnostic samples47.