No distinct highly mesenchymal population was observed, although the mitotic RMC8 cells showed the most dedifferentiated phenotype and highest expression of FN1 and CD44. SCENIC analyses of these populations identified the key MYC, YY1, and NFE2L2 regulons in the RMC cells as seen above in primary human tumours (Fig S2f). This evidence concerns the gene CD44 and neoplasm.