Comparison with bulk-RNA-seq from RMC patients relative to their NAT from both MDACC and Institut Curie cohorts showed the opposite profile with genes up-regulated in the SMARCB1-deficient tumours enriched in proliferation, cell cycle and JAK-STAT3 pathway, whereas those down-regulated associated with apical surface (Fig. 4d). The gene discussed is BRD2; the disease is neoplasm.