MAPT and Alzheimer disease: Apart of its central role in neuroinflammation, JNK kinase canparticipate in AD pathology by its implication in Tau phosphorylationand subsequent neurofibrillary tangle formation.91 It has been demonstrated by in vitro experimentsthat a JNK3 isoform can be autophosphorylated and then, it can contributeto Tau hyperphosphorylation.92 Tau hyperphosphorylationinduces its aberrant misfolding, followed by its dissociation frommicrotubules and aggregation in neurofibrillary tangles.