In summary, the data obtained in the present study indicate thatactivation of inflammatory signals and induction of Tau invivo misfolding triggered by an enriched JNK3 environmentis a significant early event during the progressive EC dysfunction.Therefore, JNK3 overexpression can lead to the triggering of cognitivedysfunction resulting in the dissemination of neurodegeneration fromEC to Hp and may be at the origin of the changes observed in earlystages of AD. This evidence concerns the gene MAPT and Alzheimer disease.