Theproof that JNK accumulation is associated with inflammatorypathway activation73 proposes the mainquestion of whether brain inflammation is involved in the early behavioraldeficits found in the present study after JNK3 overexpression induction.Inflammation is the first reaction from our body′s immune systemto pathogens or irritation and it is a two-edged sword. This evidence concerns the gene MAPK8 and inflammation.