Neurons in theEC interact extensively with hippocampal neurons, a key brain areathat features pathological signs and abundant amyloid plaques in AD.Due to the innervation of the Hp through the perforant pathway projectioncoming from the EC, we found that some hippocampal areas of AAV-JNK3-treatedmice, which seem to correspond with the molecular layer of the dentategyrus, expressed GFP (Figure 1A). This evidence concerns the gene HP and Alzheimer disease.