The large-scale analysis presented here indicates that the correlation of MALAT1 and MAPK kinase gene expression increases in melanoma and the relative expression of MALAT1 to the MAPK-pathway genes NRAS, BRAF, MEK1, MEK2, ERK1 and ERK2 is strongly reduced in melanoma, when compared to healthy skin. This evidence concerns the gene MAP2K1 and melanoma.