The relative expression of MALAT1 to all genes was significantly and strongly decreased in melanoma, when compared to healthy skin (NRAS: 38-fold; BRAF: 13-fold, MEK1: 33-fold, MEK2: 15-fold, ERK1: 16-fold, ERK2: 23-fold, for all comparisons: p < 0.001, Figure 3G). This evidence concerns the gene MAP2K1 and melanoma.