More than 80% of the cases included in our study showed a moderate or high BORIS expression which was significantly linked with the clinical stage (p = 0.013), nodal status (p = 0.049), ER expression (p = 0.039), and PR expression (p = 0.027) (Table 3) which play an important role in the progression of carcinoma of the breast. Here, ESR1 is linked to breast carcinoma.