CFTR and cystic fibrosis: Given also that healthy myeloid cells express functional CFTR (20–22) and with the replication of CF macrophage phenotypes in various total, and myeloid-specific, Cftr knockout (KO) animal models or through use of chemical CFTR inhibition in non-CF cells (10, 12–15), we can hypothesize that in addition to secondary conditioning from the inflammatory milieu, macrophage dysfunction in CF is governed by intrinsic, CFTR-related factors.