Since our previous study demonstrated that AFib cultured in the presence of the fibrotic inducer TGF-β1 possesses both a higher α-SMA protein expression and XT activity compared to CF, the purpose of this study was to establish whether this increase in myofibroblast content also impacted the wound healing properties and the temporal XT secretion rate of the cells. This evidence concerns the gene ACTA1 and cystic fibrosis.