The lower expression of significantly different levels of IL-12, IL-1β, and IL-6 increased the CD8+ T cells and rapidly decreased the CD4+/CD8+ ratio and finally induced immune cell dysregulation, which culminated in an immunosuppressive state dominated by CD8+ T cells aggravating a secondary infection and subsequently facilitating the shift from a chronic to an acute infection. The gene discussed is CD4; the disease is infection.