In the previous intravenous canine IL-31 pruritus model studies [14,15,16,17], itch behaviors of licking/chewing of the paws, flanks and/or anal region, scratching of the flanks or neck, floor pawing, head shaking and scooting were evaluated; however, there were no specific descriptions of which types of pruritic behaviors dominated after intravenous IL-31 delivery. The gene discussed is IL31; the disease is Pruritus.