A study by Rathakrishnan et al. showed that dengue patients with warning signs (abdominal pain or tenderness, mucosal bleeding, clinical fluid accumulation, persistent vomiting, hepatomegaly, increase in hematocrit with rapid decrease in platelet count, and lethargy or restlessness) exhibited high levels of IL-10 throughout the disease course, whereas those without warning signs showed decreasing IL-10 levels toward a healthy state in the convalescent phase [44]. The gene discussed is IL10; the disease is dengue disease.