IL4 and Alzheimer disease: Similarly, significant increases in IFN-γ (p = 0.0008), IL-10 (p = 0.0008), CXCL10 (p = 0.0016), IL-5 (p = 0.0070), and IL-4 (p = 0.0109) levels were observed in AD cases compared with those in HDs (Figure 3, Figure 4 and Figure 5; Table 4 and Table 5; Supplementary Figure S2).