IGHE and exanthem: Owing to levels of IL-4 and IL-5 being higher than IFN-γ levels, we hypothesize that the exanthema observed in our cohort might be attributable to the involvement of IgE-mediated hypersensitivity reactions driven by Th2-cytokine secretions (IL-4, IL-5, and IL-13), leading to an eosinophilic inflammatory reaction in the skin [66,67].