IFNG and Zika virus infectious disease: Notably, the significant increases in IFN-γ, IL-4, IL-10, and CXCL10 levels during acute ZIKV infection could reflect the presence of the virus in blood circulation or other tissue reservoirs, as opposed to the levels that returned to the normal state in the convalescent phase when the viremia often becomes undetectable in plasma and urine [43,57].