Using ZIKV NS1-based IgA and IgM ELISAs to test paired serum samples from 31 Dominican patients with RT-PCR-confirmed ZIKV infection, Warnecke et al. reported that ZIKV NS1 IgA and IgM were detected in acute samples (collected 8–16 days after illness onset) with sensitivities of 93.5% and 48.4%, respectively, but were negative in all of viremic samples, collected 2–5 days after illness onset [16]. Here, CD40LG is linked to Zika virus infectious disease.