CD4 and visceral leishmaniasis: In contrast, CD3+CD4+CD56+ NKT cells have a pathogenic profile because they accumulate at the site of infection and down-regulate CD3+CD8+CD56+ NKT cells during visceral leishmaniasis, which is due to the higher expression of CCR5 by CD4+CD56+ NKT cells compared to CD8+ NKT cells [98].