With an aim to evaluate if clinically predictive cutoffs would sharpen or blur the association of serum PFOA with the liver transaminase ALT in obese and nonobese populations, we reanalyzed the longitudinally reenrolled C8 Health population data using the two ALT cutoffs that have been designed for the early detection and evaluation of liver disease processes, and we have used that consideration as a departure point for a discussion concerning PFASs and hepatotoxicity. Here, GPT is linked to liver disorder.