CASP3 and Alzheimer disease: Keeping in view the potential role of MSCs in AKI and CKD animal models, we planned the study to evaluate protective effects of AD-MSCs and PRP against nephrotoxicity induced by methotrexate by investigating the signaling pathways’ role of Nrf2/PPARγ/HO-1 and NF-κB/Keap1/caspase-3 in the inducement and abatement of renal damage.