Tumor-associated LECs actively participate in lymphatic metastasis by highly expressing soluble semaphorin 4C (sSEMA4C), which promotes lymphangiogenesis by activating PlexinB2-ERBB2 signaling in LECs and facilitates tumor proliferation and migration by activating PlexinB2-MET signaling (7). The gene discussed is ERBB2; the disease is neoplasm.