APC and Familial prostate cancer: Genes commonly hypermethylated in prostate cancer include tumor suppressor genes involved in DNA damage repair, cell adhesion, apoptosis, cell cycle control, signal transduction, and hormonal responses, such as RARβ, GSTP1, CDH13, RASSF1A, APC, p16, DAPK, FHIT, MGMT, and CDH1 (70, 74–78).