Colorectal cancer can be further categorized into three molecularly distinct subclasses based on CIMP status: CIMP-high (CIMP-H) tumors associated with MSI and BRAF mutations, CIMP-low tumors associated with KRAS mutations, and CIMP-negative tumors associated with high p53 mutations (20, 23). The gene discussed is KRAS; the disease is colorectal cancer.