Many preclinical studies have shown that radiation may modulate the tumor microenvironment by enhancing the release of neoantigens, upregulating the expression of MHC molecules in cancer cells, increasing effector T-cell infiltration, and activating the cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) innate immune response (28). This evidence concerns the gene HLA-C and neoplasm.