For example, many pH sensitive polymers or drugs were fused with proteins such as albumin to form nanoparticles (Deirram et al., 2019; Tian et al., 2019; Zhang et al., 2020), the size of those nanoparticle will enlarge at low pH tumor site, then they were accumulated at tumor site through the enhanced permeability and retention (EPR) effect, meanwhile, escape the filtration of the glomerulus, prolong the half-life in the body, reduce dosage and side effects. This evidence concerns the gene ALB and neoplasm.