In a mouse model of Alzheimer’s disease, CX3CR1 deficiency was reported to trigger microglia dysfunction, and exacerbate neurotoxicity and phosphorylation of tau, leading to neuronal synaptic dysregulation and the impairment of memory function (Puntambekar et al., 2022). This evidence concerns the gene CX3CR1 and early-onset autosomal dominant Alzheimer disease.