IL6 and Lassa fever: Mori et al. (2017) performed a microRNA transcriptome analysis on hypertrophy of ligamentum flavum and found deregulation of hsa-miR-423-5p and hsa-miR-497-5p were closely correlated to the severity of HLF. Xu et al. (2016b) found that downregulation of hsa-miR-221 might contribute to LF hypertrophy by promoting collagens I and III expression. Hsa-miR-21 is the miRNA of SCO2. Sun et al. (2020) demonstrated that the over-expression of miR-21 was associated with the IL-6 expression, and promotes inflammation and fibrosis in ligamentum flavum.