Following thorough analysis, the homozygous TEX15 missense variant c.6835G>A, p. Ala2279Thr identified in the proband (see Case 6 in Table 2), was found to co-segregate with cryptozoospermia as it was not found in the unaffected brother and is heterozygous in both parents, indicating autosomal recessive inheritance (Supplementary Figure S1). The gene discussed is TEX15; the disease is Cryptozoospermia.