Osteoblastic inhibition by leukemia seems to be mediated by chemokine CCL3, which is increased in malignant BM cells, both in leukemic mice and patients.81 Furthermore, FLT3-ITD-positive mice showed alterations in bone morphology suggesting a possible impact of aberrant oncogenic FLT3 signaling on the process controlling bone homeostasis.85,86. Here, FLT3 is linked to leukemia.