CSF3 and acute myeloid leukemia: Indeed, different groups have tried to boost chemotherapy activity by stripping the LSCs from their niche, upon administration of granulocyte colony-stimulating factor (G-CSF) or plerixafor in combination with antileukemic treatments, with promising results.30,31 In particular, Uy and colleagues31 demonstrated an increased overall survival and relapse-free survival in AML patients treated with plerixafor in combination with chemotherapy.