JAG1 and acute myeloid leukemia: Furthermore, constitutive activation of β-catenin in OBs leads to AML development in mice.58 The increased nuclear β-catenin interacts with Forkhead box protein O1 (FoxO1), inducing the activation of Notch signaling and consequently increasing the expression of the ligand Jagged1 on OBs.59 The subsequent aberrant activation of Notch signaling in HSCs induces their leukemic transformation and ultimately leads to AML development.