This triad does not differentiate from the growing population of young-adult onset of T2D, hence a tool often used by clinicians, known as the MODY probability calculator (MPC), is used to calculate the pre-genetic-test probability (PTP) of testing positive for monogenic diabetes using a combination of broad clinical criteria (i.e., age at diabetes diagnosis, time to insulin treatment, BMI, HbA1c and family history of diabetes) (6). The gene discussed is INS; the disease is diabetes mellitus.