Importantly, we also examined variants in genes that are associated with syndromic monogenic diabetes (e.g., m.3243A>G mutation in the MT-TL1 mitochondrial gene, and WFS1), as these have been shown to be relatively common, and individuals would present overlapping diabetes phenotypes with non-syndromic monogenic diabetes (29, 30). Here, MT-TL1 is linked to monogenic diabetes.