TNFRSF1A variants can result in TNF receptor-associated periodic syndrome (TRAPS), an autoinflammatory disease characterized by paroxysmal fever, pain (chest, abdomen, muscles), rash and outwards signs of inflammation (e.g., conjunctivitis, periorbital edema) (40, 41). Here, TNFRSF1A is linked to TNF receptor 1-associated periodic fever syndrome.