A recent study shows an oncolytic IL-12-expressing HSV-1, G47Δ-mIL12, skewed TAMs to M1-like phenotype, and M1-like TAMs were further increased by triple therapy consisting of anti-CTLA-4, anti-PD-1, and G47Δ-mIL12 in the GSC-derived GBM models. This evidence concerns the gene PDCD1 and glioblastoma.