For example, M1 TAMs have the ability to generate soluble factors, including reactive oxygen species (ROS), nitric oxide (NO), TNF-α, and IL-1β, which can cause apoptosis, DNA damage, or cytotoxicity, leading to the direct killing of tumor cells (Pan et al., 2020; Aminin and Wang, 2021). The gene discussed is TNF; the disease is neoplasm.