HCN channels have been strongly implicated in the underlying pathology of depression (Lewis et al., 2011; Kim et al., 2012; Han et al., 2017; Lyman et al., 2017; Kim et al., 2018; Kim and Johnston, 2018; Cheng et al., 2019; Luo et al., 2019; Santoro and Shah, 2020). The gene discussed is MALAT1; the disease is major depressive disorder.