Additionally, CDK4/6 is disordered in numerous cancers (Wesierska-Gadek et al., 2009; Sanchez-Martinez et al., 2019; Yuan et al., 2021; Ghafouri-Fard et al., 2022; Kargbo, 2022; Yousuf et al., 2022; Zabihi et al., 2022), such as breast cancer (Gelbert et al., 2014; Chen et al., 2022; Watt and Goel, 2022), osteosarcoma (Wang and Bao, 2022), and acute megakaryoblastic leukemia (Qi et al., 2022). Here, CDK4 is linked to breast cancer.