As described in the first study of expression in the P2YR family after seizures, increased P2Y12 Rtranscription in the hippocampus and increased P2Y12 activation-mediated microglial cell membrane currents 48 h after status epilepticus (SE) were observed in a mouse model of intraperitoneal kainic acid (KA)-induced SE (Avignone et al., 2008). Here, P2RY12 is linked to status epilepticus.