Studies have revealed that PINK1/Parkin-dependent mitophagy augmentation occurred in treated PD models and exerted neuroprotective effects along with decreased p62 protein and increased Parkin and LC3-II levels (Kuang et al., 2017; Palikaras and Tavernarakis, 2020; Chaouhan et al., 2022). The gene discussed is PRKN; the disease is Parkinson disease.