PPARGC1A and Parkinson disease: Resveratrol regulated mitochondrial biogenesis and mitophagy in PD by regulating the PGC-1α, LC3-II, p62 protein-related pathways, etc. Resveratrol also promoted LC3-II accumulation, inhibited p62 expression and augmented autophagic flux, which was inhibited by rotenone in SH-SY5Y cells (Lin et al., 2014; Lin et al., 2018).