A significant resveratrol (25 μM) -mediated increase in the PGC-1α transcriptional activity of downstream genes TFAM and COX 1, the mtDNA/nDNA ratio, and enhanced macroautophagic flux through upregulating LC3-II levels was observed in skin fibroblasts from PD patients (Ferretta et al., 2014). Here, TFAM is linked to Parkinson disease.