N-acetylglucosamine aminotransferase V (GNT-V) is highly expressed in M2 macrophages in SSc skin samples, and knockout of GNT-V in bleomycin (BLM)-induced SSc mouse model dramatically reduced CD163+M2 macrophages, dermal thickness, and collagen 1α1 expression [51]. Here, CD163 is linked to systemic sclerosis.