It reveals that hsa_circ_0026817-hsa-miR-211-5p-CACNA1C, hsa_circ_0007215-hsa-miR-1252-5p-MECP2, and hsa_circ_0007215-hsa-miR-1343-3p-RBL1 axes may play a crucial part in CAVD and may provide new insights into the pathogenesis and therapeutic targeting of CAVD. This evidence concerns the gene MECP2 and congenital bilateral aplasia of vas deferens from CFTR mutation.