Overall, our analysis highlights various infection-related pathways, i.e., epstein–barr virus infection, p53 signaling pathway, FOXO signaling pathway, TGF-beta signaling pathway, cell cycle cellular senescence, pathways in cancer, metabolic pathways, autophagy, and hedgehog signaling pathway which might be the potential links between both COVID-19 and HFRS. This evidence concerns the gene TP53 and COVID-19.