FASN and obesity due to melanocortin 4 receptor deficiency: Interestingly, besides dyslipidemia, adult animals with childhood obesity also presented lipid accumulation in the liver, observed by increased liver TG content, accompanied by increased DNL, seen by enhanced expression of FASN in the liver, following previous studies (Duff and Snell, 1982; Ribas-Aulinas et al., 2021; Yang et a., 2018).