FASN and obesity due to melanocortin 4 receptor deficiency: Accordingly, the role of glucocorticoids as an important modulator of energy balance in obesity induced by early overnutrition was also demonstrated in the current work, where ADX was able to reduce body weight gain and food intake, to induce an improvement in lipid profile, with reduction of FFA, TG, total and LDL cholesterol, and to reduce TG content as well as expression of FASN in the liver of SL animals, and treatment with corticosterone could restore most of these changes induced by ADX.