LOX and hypertensive disorder: It has been reported that intracranial aneurysms can be induced by the degradation of the vascular wall caused by the use of elastase and lysyl oxidase inhibitors, as well as hypertension caused by a high-salt diet, continuous infusion of angiotensin II and ligation of the right renal artery, but the methods are complex and there are many uncontrollable factors (Patel et al., 2021).