In a model of unilateral ureteral obstruction, sphingosine-1-phosphate promotes macrophage glycolysis and inflammation via the sphingosine kinase 2 (Sphk2) pathway, suggesting that sphingolipid signaling may be a critical immunometabolic regulator in kidney injury (Ghosh et al., 2018). The gene discussed is SPHK2; the disease is Ureteral obstruction.