HMGB1 and Sepsis: Therefore, in intensive care, high serum histone and HMGB1 levels have been reported to be associated with sepsis severity and prognosis.2,3 Previous research in our lab revealed that extracellular histones can be found in the lungs and liver of an endotoxin shock mouse model via immunofluorescent staining.23 In this study, histone H3 and HMGB1 were detected in the serum of postoperative patients requiring intensive care.