NPPB and diabetes mellitus: We assessed the effect of adding BNP and urinary albumin to the basic risk factors comprising sex, age, systolic blood pressure, HDL-cholesterol, LDL-cholesterol, hemoglobin, eGFR, history of CVD, and diabetes.11–13 We found that adding BNP and urinary albumin improved the predictability for cardiovascular–renal events after follow-up for 109 months beyond that using the basic risk factors alone, as follows: C-index, 0.767 (95% CI, 0.728–0.814; p=0.009); NRI, 0.497 (p<0.0001); and IDI, 0.071 (p<0.0001).