Urinary albumin, a representative urinary biomarker, is related to cardiovascular disease (CVD) and death as well as to renal prognosis.4 Brain natriuretic peptide (BNP), a representative cardiac biomarker, was shown to be useful as a diagnostic, prognostic, and therapeutic indicator of heart failure (HF).5 To date, there have been no reports that investigate the combined predictive value of BNP and urinary albumin for long-term cardiovascular–renal events in patients with CKD. The gene discussed is NPPB; the disease is chronic kidney disease.