A meta-analysis showed a decrease in the hospitalization rate due to HF, CVD, or all-cause mortality when patients underwent BNP-guided therapy.22 A drug-induced reduction in urinary albumin was also found to be renoprotective.23 On the basis of the indications for drugs that have been shown to inhibit both cardiovascular and renal events, evaluating BNP combined with albuminuria might help to improve patients’ prognosis. The gene discussed is NPPB; the disease is hydrops fetalis.