CXCL12 and cancer: Cancer-associate fibroblasts (CAFs) are major drivers of extracellular matrix (ECM) remodelling, angiogenesis and immunosuppressive mediator expression in the TME, including lactate, adenosine, arginase, indoleamine 2,3-dioxygenase (IDO) as well as multiple inhibitory cytokines and chemokines, particularly TGF-β and chemokine (C-X-C motif) ligand 12 (CXCL12).