Mechanistic experiments turned out that CAFs-EVs can carry SNHG3 into CRC cells and upregulate HuR expression by competitively binding to miR-34b-5p, which in turn promotes the binding of HuR and HOXC6 and enhances the transcription of HOXC6 and promotes the malignant progression of CRC (122). This evidence concerns the gene HOXC6 and colorectal carcinoma.