TGFB1 and colorectal carcinoma: Sustained autocrine TGF-β1 activates CAF and releases more exosomal miR-17-5p into CRC cells, thus forming a positive feedback loop for CRC progression (124) LINC00659 expression was significantly increased in the exosome of CAFs, which could transfer exosomel LINC00656 to CRC cells and promote cell proliferation, migration, invasion and EMT progression.