Besides, dysregulation of IL-1β, IL-5, IL-6, IL-9, IL-17, granulocyte colony-stimulating factor, monocyte chemotactic protein-1, TNF-α, and IL-4 were observed in mevalonate kinase deficiency patients and mice (82). The gene discussed is TNF; the disease is hyperinsulinemic hypoglycemia, familial, 4.