This was associated with decreased IFN-γ-producing CD4+ and CD8+ T cell but not IL17A-producing Th17 cells (data not shown) in the DTH model, and reduced CD4+ and CD8+ T cell infiltration in tumor model, especially inhibition of CD8+ T cell effector activity and increased CD8+ T cell exhaustion, suggesting Ccdc134 deficiency affects more CD8+ T cells than CD4+ T cells. This evidence concerns the gene CD8A and neoplasm.